Once global pacing, tone, palette, etc., are established in your story art, then you can go through and focus on all of those big picture things again, but page by page.
Simon's New Bed by Christian Trimmer and illustrated by Melissa van der Paardt has a fantastic example of how you can push POV/perspective in just one spread to completely change the entire emotional tone of the story:
Lauren shares the initial sketch of the scene where dog Simon comes into the room ready to use his new dog bed for the first time... And cat Miss Adora Belle...
The editorial team likes this sketch very much, but they ask Melissa to push the drawing even farther, to visually interrupt what had been a light and breezy, happy day of anticipation for Simon in these two earlier spreads:
And "stop the music" as Lauren says in the spread in question. And Melissa comes back with this:
Environment is the same, characters are the same, but look at all you can achieve with just a shift in camera angle!
And even with the POV change, the editorial team wants things to go one step further. Since this scene is the big shifting moment in the story's emotional arc so far, changing up the lighting and palette compared to the earlier spread will help underscore the change in the story's tone even more.